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KMID : 0371319720140110017
Journal of the Korean Surgical Society
1972 Volume.14 No. 11 p.17 ~ p.23
Clinical Evaluation of Nodular Thyroid Disease


Abstract
One of the reason for advocating removal of all nodular lesions of thyroid gland has been the fear
of malignancy because the nature of these nodules cannot be determined preoperatively with any
degree of certainty.
An excision biopsy for frozen section is available in the operating table, but frozen sections are
often difficult to interpret because some malignant tumors may be benign in appearance and
malignant in behaviour or vice versa.
And we present the results of frozen sections (90 cases) and clinical findings of 355 cases of
nodular thyroid diseases operated during the 12 year period from Aug. 1959 to Aug. 1971 at the
Dept. of general surgery of National Medical Center.
1. Thyroid cancers were 110 cases (31.9%) among the 355 cases of nodular thyroid disease.
2. The most frequent type of thyroid cancer was papillary type (78.2%)
3. Female was more frequently affected by both benign and malignant nodular thyroid disease
than male with the ratio of 9 : 1 and 7 : 1 respectively.
4. Benign nodular thyroid disease was prevalent in third decade (33.1%) and also the thyroid
cancer was prevalent in third decade (29.1%)
5. Average symptom duration before presentation of benign and malignant thyroid disease were
5 years and 4 years respectively.
6. Cancer incidence of solitary nodule was 29.3%.
7. Accuracy of clinical diagnosis of thyroid cancer was 76.4%.
8. Frozen section made in 90 cases (21.1%) of nodular thyroid disease and its false positive was
3.3% and false negative 11.1%.
9. The most frequent post-op. complication of thyroid surgery was transient hypoparathyroidism
(19 cases).
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